What is Chemical Genetics?
Chemical genetics refers to studying molecules, specifically smaller molecular components, and their influence of the function of a gene or protein of interest [1]. The interaction of small molecules with genes and proteins may serve as prime targets of drug therapy and treatment for human diseases, and could potentially lead to prevention of fatal cases of Von Willebrand's Disease in the face of disrupted VWF protein function.
Discussion
Pubchem is a database that can be used to look specifically at molecular data and consequential annotations to find targets for drug therapies [2]. For VWF, there are over 38,000 total molecular annotations that may serve as potential drug avenues for treatment.
References:
[1] Stockwell, B. R. (2000, November 1). Chemical Genetics: Ligand-based discovery of gene function. Nature reviews. Genetics. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171795/
[2] U.S. National Library of Medicine. (n.d.). Open targets - pubchem data source. National Center for Biotechnology Information. PubChem Compound Database. https://pubchem.ncbi.nlm.nih.gov/source/25955#data=Annotations
[1] Stockwell, B. R. (2000, November 1). Chemical Genetics: Ligand-based discovery of gene function. Nature reviews. Genetics. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171795/
[2] U.S. National Library of Medicine. (n.d.). Open targets - pubchem data source. National Center for Biotechnology Information. PubChem Compound Database. https://pubchem.ncbi.nlm.nih.gov/source/25955#data=Annotations
This web page was produced as an assignment for Genetics 564, a capstone course at UW-Madison.
Michelle Conte | [email protected] | Last edited 05/08/2024 | www.genetics564.weebly.com