Protein Interaction Networks
Protein interactions refer to proteins that work together to achieve a certain biological function, specifically the protein structures that come into contact with one another. Understanding protein-protein interactions is a fundamental step to understanding how a particular protein's function may be involved in certain pathways [1]. Networks of these relationships can be constructed and are known as Protein Interaction Networks. Using databases such as STRING, VWF protein interactions with other proteins are arranged in a web-like network and reveal proteins with significant involvement and relation to VWF characteristics [2].
VWF Protein Interaction Network- Humans
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VWF Protein Interaction Network- Danio Rerio
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The proteins within these networks have been identified to play a role in the biological process, molecular function, and cellular component of VWF protein.
Discussion
The protein interaction networks provide key information to the functions of VWF in both humans and zebrafish, most especially on how they compare. There are proteins in the human interaction network that are associated with platelet activation, collagen binding, and platelet granules. Additionally, in the zebrafish interaction network, there are a number of protein homologs to those located in the human interaction network. For zebrafish, gene ontology relations are closely related to each of the terms of the VWF gene in humans. Each of these networks show that the role of VWF in platelet activation and vascular hemostasis is likely related to the functions of other proteins in similar biological pathways. The output from protein interaction networking builds a foundation of interest into the specific proteins that have similar roles to VWF, as well as their mechanisms for interaction.
References:
[1] Rao, V. S., Srinivas, K., Sujini, G. N., & Kumar, G. N. (2014). Protein-protein interaction detection: methods and analysis. International journal of proteomics, 2014, 147648. https://doi.org/10.1155/2014/147648
[2] String: Functional Protein Association Networks. (n.d.). https://string-db.org/cgi/network?pollingId=bjX4TE78ubuS&sessionId=bKLO7v3gAldc&urldisam=brWiMNBXKBiX
[1] Rao, V. S., Srinivas, K., Sujini, G. N., & Kumar, G. N. (2014). Protein-protein interaction detection: methods and analysis. International journal of proteomics, 2014, 147648. https://doi.org/10.1155/2014/147648
[2] String: Functional Protein Association Networks. (n.d.). https://string-db.org/cgi/network?pollingId=bjX4TE78ubuS&sessionId=bKLO7v3gAldc&urldisam=brWiMNBXKBiX
This web page was produced as an assignment for Genetics 564, a capstone course at UW-Madison.
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